Publications

2019

Medel B, Costoya C, Fernandez D, Pereda C, Lladser A, Pacheco R, Iwawaki T, Salazar-Onfray, Osorio F. IRE1α activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming. Frontiers in Immunology 2019, 9:3050.

2018

Osorio F*, Lambrecht B and Janssens S*. 2018. Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways. Current Opinion in Immunology 2018, 52: 100-107. * corresponding author.

Garcia-Gonzalez P,Cabral-Miranda F, Hetz C, Osorio F. 2018. Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases. Frontiers in Immunology 2018, 9:2541.

2017

Tavernier SJ*, Osorio F*, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu A, Lambrecht BN and Janssens S “Regulated Inositol-Requiring Enzyme 1 dependent mRNA decay sets the threshold for dendritic cell survival”. Nature Cell Biology 2017. 19, 698-710. doi:10.1038/ncb3518. * co-first author 

2016

Contreras F, Prado C, González H, Franz D, Osorio-Barrios F, Osorio F, Ugalde V, Lopez E, Elgueta D, Figueroa A, Lladser A, Pacheco R. “Dopamine Receptor D3 Signaling on CD4+ T-cells Favors Th1- and Th17- mediated Immunity”. The Journal of Immunology 2016 , 196: 000-008.

2015

Castillo V, Oñate M, Woehlbier U, Rozas P, Andreu C, Medinas D, Valdés O, Osorio F, Mercado G, Vidal RL, Kerr B, Court FA, Hetz C. 2015. Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration. PLoS One. 11; 10(9):e0136620. doi:10.1371/journal.pone.0136620. eCollection 2015.

 Osorio F*, Fuentes C, López MN, Salazar-Onfray F, González FE*. 2015. Role of Dendritic Cells in the Induction of Lymphocyte Tolerance. Frontiers in immunology. Oct 20; 6:535. * corresponding author

2014

Osorio F, Tavernier S, Hoffmann E, Saeys Y, Vetters J, Delrue I, De Rycke R, Parthoens E, Poulliot P, Iwawaki T, Janssens S and Lambrecht B.N. 2014. The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells. Nature Immunology 15 (3): 248-257.

Editorial comment in:

-Signalling: new roles for cell stress sensor. Nature Reviews Immunology. 2014

-A new RIDDle in DC-mediated cross-presentation. News and views; Nature Immunology. 2014.

Whitney PG*, Bär E*, Osorio F, Rogers NC, Schraml BU, Deddouche S, LeibundGut-Landmann S, Reis e Sousa C. 2014. Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection. PLoS Pathogens. Jul 17;10 (7):e1004276. doi: 10.1371/journal.ppat.1004276.

González FE, Gleisner MA, Falcón F, Osorio F, López MN, and Salazar-Onfray F. 2014. Tumor cell lysates as immunogenic sources for cancer vaccine design. Human Vaccines & Immunotherapeutics. 10(11) 3261-3269.

2013

Osorio F, Lambrecht BN and Janssens S. 2013. The UPR and lung disease. Seminars in Immunopathology. 35(3) 293-306.

2012 and earlier

Kool M, Willart MA, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, Rogers N, Osorio F, Reis e Sousa C, Hammad H and Lambrecht BN. 2011. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 34 (4): 527-540.

Osorio F and Reis e Sousa C. 2011. Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 34 (5) 651-664.

Rosas M, Osorio F, Robinson MJ, Davies LC, Dierkes N, Jones SA, Reis e Sousa C, Taylor PR. 2011. Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European Journal of Immunology 41(2): 356-365.

Robinson MJ*, Osorio F*, Rosas M, Freitas RP, Schweighoffer E, Gross O, Verbeek JS, Ruland J, Tybulewicz V, Brown GD, Moita LF, Taylor PR, Reis e Sousa C. 2009. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. Journal of Experimental Medicine 206(9): 2037-2051. * Co-first author

Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G and Reis e Sousa C. 2008. DC activated via dectin-1 convert Treg into IL-17 producers. European Journal of Immunology 38(12): 3274-3281.

Leibundgut -Landmann S, Osorio F, Brown G.D and Reis e Sousa C. 2008. Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood 112(13): 4971-4980.

LeinbundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C. 2007. Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nature Immunology 8(6): 630-638.

Ureta G, Osorio F, Morales J, Rosemblatt M, Bono MR, Fierro JA. 2007. Generation of dendritic cells with regulatory properties. Transplantation Proceedings 39(3): 633-637.

Bono MR, Elgueta R, Sauma D, Pino K, Osorio F, Michea P, Fierro A, Rosemblatt M. 2007. The essential role of chemokines in the selective regulation of lymphocyte homing. Cytokine Growth Factor Reviews 18: 33-43

Laboratorio de Inmunología y Estrés Celular
Immunology Program
Institute of Biomedical Sciences (ICBM)
Faculty of Medicine
University of Chile

Avenida Independencia 1027
Block I, 3rd Floor
Post code 8380453
Santiago, Chile
Phone number: +56229789598